89 thoughts to “COVID-19 Genetics | Science News 2.1”

  1. I'd love to hear about the test kits themselves, about whether they are hard to manufacture and about how it would be possible to make more tests to more people.
    Stay safe!

  2. Remdesvir and how it is supposed to help fight against the coronavirus. I work in a grocery store and I cannot hunker down in my house… It has been busy but the side effect of growing demand and no school is my ability to work more. Hopefully I do not get sick or have been sick because I interact with so many people in such a confined and personal space where transmissions are easiest.

  3. What's this thing: a test protocol for viruses. I'm super curious how this kind of test works, and the logistics of sharing them with other labs/scientists. Thanks for sharing your knowledge and creating more brain power in the world!

  4. Thank you for the information and look forward to the livestream. Notable moment of both seriousness and tenderness, the "go forth, do science" as "stay put, and wash your hands" was a wonderful, heartwarming, and heavy touch that solidified the gravity more than most things.

  5. Hi, Alex. I've looked up the NYTime's infographic and, just out of curiosity, what are the timescales we're talking about? From the time it takes the virus to attach, replicate its RNA and destroy the cell? (I tried but couldn't find the answer.) Thank you.

  6. I don't know if you have any information on the testing for a vaccine they're reportedly already doing on humans, but that could be of interest.

    Personally, I've wondered, if we do manage to stop the spread now… how likely is it to spread again next year or something? Are we hoping to stop it now and just have a vaccine deployed by the time it comes around again?

    But both those questions may be more for a virologist and not, as you said, about the genetics. So NBD if you don't want to address those. Sorry I don't have better genetic-specific questions.

    As for the last part of the video, yeah, I'm not worried about myself getting it — I'm a very healthy, relatively young (mid 40s — "young" enough for this situation) person. I am concerned about getting it and then spreading it to others who are more at risk — like my parents, who are in their 70s, and especially my father, who only has one lung left. Or for a friend's friends she mentioned in Seattle (lots of infected people already) who are highly at risk (lungs and immune deficiency) and have confirmed infected people in their apartment complex.

  7. Hey,
    I know this is gonna sound odd.

    But do you mean 1200h PST or 1200h PDT.

    I know you are currently in California, which currently observe Daylight saving time which would put you at 1200h PDT on your clocks which makes it 1900h UTC but 1200h PST would be 2000h UTC……

    Daylight saving is the worse, and ruins all.

  8. What do we know about the mutability of SARS-CoV2 as it spreads through populations? Does it have a propensity for recombination, and if so, should we be worried about escape mutants specifically regarding the Roche and Thermo Fisher assays?

  9. I really wish I had a better understanding of PCR, if there's a way you can explain how that works for us lay-physicists?

  10. I think you meant 12pm PDT not PST. And thank you for including the UTC time which we should all be using anyway!! I will try to be there and ask if there is any evidence that some people are genetically predisposed to be less affected by the coronavirus.

  11. Great video Alex! Thanks for the clarity and passion as always. Forgive my ignorance on human genetics, but I have several questions about how genetics plays a role in this pandemic.

    1) Are there demographics of people who are genetically predisposed to certain kinds of viral infections? Perhaps genetic immunity?
    2) Is the reason this virus infects humans and not other mammals/animals a genetic one?
    3) On a non-genetic note, do you foresee mutations of Covid-19 prolonging the effects of the pandemic even after a vaccine is developed?

  12. Why do you think the testing kit is qRT-PCR instead of just RT-PCR? Having quantitative output seems to be unnecessary if the goal is to get a binary answer.

  13. Important naming clarification that was not clear in this video: The virus itself is called SARS-CoV-2, and the disease that it causes is called COVID-19. I will reiterate this in the livestream to try and keep everything straight.

  14. I'm not sure, if all of those questions are in your subject, but that's something that interests me.

    Is the difference between RNA and DNA viruses also reflected in the size of a virus?

    Are there differences in mutation-rates between DNA and RNA viruses?

    How much does a virus need to mutat, so that the immunity is no longer given?

    How different is SARS-CoV-2 from the SARS virus a few years ago?

    @all: stay home, stay healthy, stay in contact using Skype, Discord and other media. Humans are social and we need to be in touch with others. Since we can't physically right now, do so at least virtually.

  15. hoe deadly do you think this virus is compared to the other pandemics we have experienced in the past. yes it spreads much easier but with its death rate of only 2% many young people are treating it as something minor and saying that people and media is overreacting, because common cold and other common diseases have a much higher death rates. and can we actually vaccinate people over 50 when we finally do have a vaccine for this? they're the most vulnerable to this virus.

  16. I’d love to review different “strains” of the virus. How many are there, how do they differ and if there’s any health relevance to the differences

  17. In the early days I read that samples are tested three times and only declared positive if all three tests come up positive. Maybe you could explain why that was done?
    And a friend (environmental engineer) mentioned primer dimer and that it can lead to false negatives in PCR. Topic for a tangent?

  18. As someone in home quarantine I appreciate youtube videos a lot, thank you for making them. Now for some questions. I mainly have questions about mutations in the virus. Does the type of genes in the virus (RNA vs DNA) have any significant impact on how quickly it can mutate? I have heard some stories that different strains of SARS-CoV-2 were used to keep track of the way it spread. Do you know wether this is could be true? And how easy/hard would it be to identify the different strains? This also makes me wonder how much of its RNA is actually expressed.
    Anyway, to anyone reading this: good luck, stay safe, stay calm and call your grandparents if you have any 😉

  19. I really appreciate the clarity on these videos on between what you do know and do not claim to know/be an authority figure about. From the point of view from a uni student trapped in their very small dorm room.

    Cheers.

  20. Really interested to learn about how the tests work and how they are manufactured. For example, how are they able to quickly mass produce tests for new viruses like SARS-CoV-2? Also, is there any way for geneticists and virologists to know if a particular virus is likely to behave like cold and flu, mutating to produce new strains every season? Thanks!

  21. One silly question I would like to ask is exactly how is a virus neutralised by cleaning agents? My understanding as a chemist is that proteins are denatured by oxidation or replacement of water molecules.

  22. I would love to learn more about the qPCR! It's a word that's been tossed around in the lab a lot and I would love to learn the concept in the coronavirus context. Thank you for making the videos!

  23. I have used your videos in my biology class for years!! My students and I will be tuning in Friday 🙂 Thank you!!

  24. Alex, First I would like to thank you for your amazing videos. I really don’t have a question but maybe a suggestion.

    I’ve homeschooled my daughter for 8 years and from time to time I’ve used your videos to spark her interests. With a good amount of kids being home from school. This might give you an amazing opportunity to make some Science 101 video for kids. Thank you for all that you do! You are inspiring so many little girls.

    Go forth, wash your hands and do science!

  25. I would like to know more about the vaccines being developed. What type of vaccines are they? And how reliable would you expect them to be and for how long? How mutable is the virus compared to other viruses like the seasonal flu, for example, and how would this pandemic evolve in the future given the nature of the viral genome we are dealing with. Also what is the molecular mechanism through which the virus infects the body? How is it for other corona viruses?

    Thank you! Love from Europe. I watched your last live stream while doing a FISH on my transgenic Drosophila embryos. I love your videos and how relatable your journey feels to me (I am also here to learn…the hard way).

    Go forth, do science!

  26. So good start. Some of your information is already out of date. The assumption that the virus only uses ACE2 receptors is not complete. There are 3 other receptors that have been determined. Some only go to the cell surface when the cell is under stress. This is what makes this virus more virulent than others. Also, you do not mention the elephant in the room – that this is a manufactured virus. You do not go over the evidence that there are exact portions of other related viruses in this virus – specifically HIV spike protein. Would be nice if you could review the paper that was immediately retracted because the "medical establishment" did not want the truth to be well known.

  27. Well I'd like to know how can we stop the virus replication although the vaccines contains pathogeneic microbes to fight it but is there a way to engineer the virus and shut it off.
    I'm a biotechnology student and I'd really love to hear your thoughts.
    Hope U see my comment 💙💙

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  29. Thank you. I've watched your channel for quite some time and always appreciated the way you can make the complicated easier to understand. I look forward to your Friday live stream.

    I see too many people pushing misinformation. They need to stop getting skewed information from social media. For accurate details, their source should be the CDC or the WHO. They are your front lines for true information.

    I work for a health insurance company (WFH now). We see the numbers and understand the true impact. Yes, the young and the healthy are not as susceptible. But this is highly contagious and can be critical to older people or anyone with a compromised immune system.

    If too many people get sick at once, this will easily overburden our Healthcare system. That's when the most vulnerable get cought outside the loop. That's when people die unnecessarily. Anything people can do to alleviate this should be done.

    Follow the restrictions suggested by the authorities. Limit direct contact, go under a self imposed quarantine, practice social distancing, and frequently wash. This is not a game. It needs to be done to prevent unnecessary deaths.

    It may be a minor thing to you and a large number of people may show no symptoms or easily recover However, it is too easily spread to the groups more likely to succumb. It can too readily take resources away from the older and more infirm because of the backlogs it causes.

    No, it is not the time to panic. It is not the time to go out and hoard all the necessities and prevent an equitable distribution of them.

    It is the time to act responsibly. It is the time to heed the restrictions. This is the definition of a moral imperative.

  30. I am wondering about mutations and is it possible that the virus interactions differ from one population to another?
    The other question, what is next when it comes to immunity of oneself from a genetics prospective?

  31. Hi Alex ! This is a very good idea ! If I may ask you 2 questions: how does a test kit work for this specific COVID-19 ? (is there a traditionnal approach, and new testing strategies ? not sure it's related to genetics anyway) and: Is there a chance that genetics could help protecting people from this specific virus ? (is there a way to hack/block this ARN from working once in place ?) Thanks a lot. You're a wonderful teacher 😉

  32. Hi Alex – I would love to hear your insight into the potential of SARS-CoV-2 virus to further mutate as it spreads? Also, what is your take about Moderna mRNA vaccination for this COVID-19? How can mRNA of the virus be used to make its vaccination? Would it make more sense to make antibody against its ligands? Hope you and family are well. Be safe and thank you for all the information you share 🙂

  33. "Stay put & Wash your hands". Loving the new tag line.
    Would love to hear about how exactly a test for a specific virus works. Still seems like magic to me.

  34. I am really interested about all what you said i hope if you just extend the video series to 3 or 4 parts to talk more about the three topics that you mentioned because it's very interesting
    thanks

  35. Thanks – a rather clear explanation. Even this old, as in 73, computer geek understood you explanation.
    I saw the movie "Contagion" when it first came out and again on cable about 3 weeks ago.
    One of my favorite lines was "This thing is figuring us out faster than we are figuring it out." How relevant is that concept to this current SARS-CoV-2 virus?
    Also, younger folks seem to be less vulnerable than are those my age.
    Stay safe and stay healthy.

  36. It's such great news to be informed about the virus by a geneticist! I'm so glad I subscribed to your channel, Alex! Will definitely stay tuned for the livestream 🙂

  37. The one thing I have been wondering, and it may not be in your field, is why this virus does not seem to kill kids, like at all. I mean is it more than just them being more resilient than adults/the elderly?

  38. In our household we had a cough for a week but otherwise felt the same.
    When we woke up the cough was light to moderate and lasted most of the morning. Scant amount of sputum was occasionally expectorated. No temperature. Neighbors also said they had the same symptoms of just the month long cough. We are wondering now what did we have. Corona? We debated all month if we should see the doctor but felt they would think nothing of it. Any clue?
    T

  39. Is there a direct link that can be shared? I am currently showing this video to my classes and would like to share the live feed link if possible.

  40. what are chemical bonds that may stabilize “spike” protein in coronavirus, , why each of which occurs ?

  41. Can I post another question besides this one? It goes like this: what is the meaning that the virus found in Brazil has 16 mutations that differentiates it from the one in Wuhan? I imagine that the proteins it synthesise after infecting the host cell are different, and how different depend on the mutation itself, but how significant can this be?

  42. What happens when you merge C22'H22'Br'N2O3'S with C33'H25'F6'N3'O3. I'm not scientist but I'm curious what happens when you merge these… Hm, sorry, stoichiometry is horrible for me. Haven't done it since 9th grade in high school. Also have you heard of Viperin enzyme

  43. The livestream will happen 3am here in the Philippines sadly. I wonder if ill still be able to watch the replay 🙁

  44. Whoa I've been subscribed to you for longer than I can remember but this is the first time youtube has recommended your videos to me- I think I subscribed from a collab with tom scott or vsauce or something? The algorithm is really messed up. I love your stuff and will probably binge it tomorrow XD

  45. I’d love to hear about your experience with PCR, and it’s application with covid
    I would also like to hear about Covids sequencing, infection clusters and tracing transmission. Also any mutations that are present.

  46. Just got back here from the live stream. ​Thanks again for the videos! How did we isolate COVID-19 virus when it was done for the first time when the test kits for this virus were absent?

  47. Dispute over Italy Patient zero
    There is a discussion ongoing whether it was one of the early German patients (Webasto-company members) who brought the virus to Italy. US geneticists say so, but other experts are more sceptical. They say, the genetic variations of covid-19 found in Italy do not match with the so called Webasto-hypothesis. What do you think as an independet geneticist?

  48. I'm a Bsc student and after hearing about this virus from everyone around me I have a curiosity to know about this virus. So can you please explain me the structure of this virus and the mechanism about how it works. 🤓

  49. The cringey part of this is the acquiescence to the notion that this virus is natural and zoonotic. I watched that molyneux interview that mentioned copypasta gene insertions strongly implying human ‘geneticists’ [super cringe] had at some point tampered with a strain of the sars virus.

  50. Thank you for this video, Alex. Added it to my little 24-hr heath channel, ( truestrangenews.com/24-hr-health-channel/). Q: For any geneticist: What is the world population breakdown of common polymorphisms of ACE2? One SNP is rs2106809. ( https://www.snpedia.com/index.php/Rs2106809 ) and 23andme lists 13 others. If we knew this, could we start to ask other questions like: "Do genetic differences in ACE2 result in more vulnerability to the Covid-19 causing virus?" and "Can those of us who had done the 23andme thing determine our vulnerability to the virus in this way?" The more we know, the better we can feel that we are doing all we can to fight this. Update: found this ( https://www.nature.com/articles/s41421-020-0147-1 )

  51. Keep up the good work Alex. All of your videos are informative. Please don't stop creating amazing videos.

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